Research Interests
We are interested in studying the molecular mechanisms of antibiotic resistance. Mycobacterium abscessus, is a rapidly emerging nontuberculous mycobacteria (NTM) in patients with cystic fibrosis and underlying lung damage is considered an ‘antibiotic nightmare” due to its intrinsic resistance to the majority of FDA approved antibiotics. M. abscessus therefore offers a unique opportunity to explore the potential of drug resistance mechanisms encoded by bacteria. In addition, we are also interested in studying transcriptional networks involving sigma factors and their regulators in mycobacterial physiology.
Specific projects include:
- Systems level understanding of changes that accompany exposure of M. abscessus to antibiotics with a specific focus on the WhiB7-dependent pathway.
- Mechanisms of HflX & ABCF mediated resistance to macrolide-lincosamide antibiotics.
- Mechanisms of HelR mediated resistance to rifamycins.
- Identification of effectors that confer unique profiles of drug resistance.
- Screening of small molecule libraries for inhibitors of identified targets.
- Exploring phage lysins as an alternate therapy for M. abscessus infections.
To learn more about our projects and the people behind them, visit our Research Projects and People page.
Join our lab!
We are looking for motivated PhD students! Projects include the study of antibiotic drug resistance and the mechanisms of gene regulation in non-tuberculous mycobacteria. Lab members and the research projects are supported by the National Institutes of Health.
Feel free to contact Pallavi.ghosh@health.ny.gov for more information about our laboratory.
Research Affiliate I (Post Doctoral) JR-0001382
Research Affiliate I (Post Doctoral) JR-0001382
Applications due 2/25/25
Health Research, Inc. is seeking a Research Affiliate I. The Research Affiliate I will utilize their PhD-training to work on research projects under the guidance and mentorship of the Principal Investigator (PI). The incumbent will join a research laboratory dedicated to the molecular mechanisms of regulation of drug resistance in mycobacteria. Core responsibilities of the position include planning and conducting experiments, assisting the Principal Investigator with student training and lab management activities, data analysis, manuscript preparation, and presenting findings at conferences and internal meetings. The incumbent will apply their training and broaden their technical skills towards planning and carrying out independent experiments in conjunction with the Principal Investigator. More information about research projects can be found here: https://www.wadsworth.org/research/laboratories/ghosh-laboratory/resear…
This position will be part of a dynamic team serving the Wadsworth Center’s mission in the New York State Department of Health’s efforts to protect and promote the health of New York’s citizens. Come be a part of Science in the Pursuit of Health®!